Nanovista’s first product, CF800, is a liposome nanoparticle-based imaging agent that:
- Helps cancer surgeons clearly identify tumor boundaries prior to and during surgery for a more complete removal of tumor tissue while preserving healthy tissue
- Holds a strong scientific basis and demonstrated performance in animal studies
- Contains components that are FDA-approved and shown to work with multiple imaging techniques
- Is a long-lasting agent (2 weeks) compared to alternative agents that require multiple injections (minutes or hours)
- Utilizes existing clinical infrastructure and 800nm fluorescence imaging systems, already adopted in most major cancer centres and quickly gaining widespread acceptance in surgical oncology
CF800 (Figure 1) is currently being advanced for Phase I trials.
Figure 1. Preclinical illustration of the imaging performance of CF800 for image-guided surgery in a rabbit head and neck cancer model. Volumetric CT imaging (top) allows for preoperative surgical planning as well as intraoperative cone-beam CT guided resection. Near-infrared fluorescence imaging (bottom) enables real-time high sensitivity detection of the surgical margins and lymph node status.
Publications
A multimodal nano agent for image-guided cancer surgery.
Zheng J, Muhanna N, De Souza R, Wada H, Chan H, Akens MK, Anayama T, Yasufuku K, Serra S, Irish J, Allen C, Jaffray D.
Biomaterials. 2015 Oct;67:160-8. doi: 10.1016/j.biomaterials.2015.07.010. Epub 2015 Jul 14.
PMID: 26218742 Free Article
Intellectual Property
Nanovista holds a strong intellectual property position for multimodality imaging agent composition and methods of use. Patents have been issued in the US, Canada, and the EU. An additional patent application in the area of multimodality imaging is currently pending.